WGC2021

The 11 ^thWorld Gene Convention - 2021

Program

Time: September 25-27, 2021

Venue: Dalian International Conference Center (DICC), Dalian, China

Registration

Time: 08:00-18:00, September 24, 2021 (Friday); Place: Lobby, 1F, DICC

Opening Ceremony

Time: 09:00-09:25, September 25, 2021 (Saturday); Place: Room 302, 3F, DICC

Plenary Forum (Part I)
Time: 09:25-12:30, September 25, 2021 (Saturday); Place: Room 302, 3F, DICC

Moderator	*Dr. Lixin Zhang,* Professor and Director, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, China

09:25-09:30	Moderator's Introduction
09:30-09:55	*Title:* Highly Potent Pan-CoV Fusion Inhibitors and Pan-sarbecovirus Vaccines against SARS-CoV-2 and Its Variants *Dr. Shibo Jiang,* Professor and Director, Institute of Medical Microbiology, Fudan University, China
09:55-10:20	*Title:* Nongenomic Actions of Nuclear Receptors and their Implications in Drug Development *Dr. Xiaokun Zhang,* Professor and Dean, School of Pharmaceutical Sciences, Xiamen University, China
10:20-10:45	*Title:* Drug Research Based on Protein-Protein Interaction *Dr. Qidong You,* Professor and Director, Jiang su Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, China
10:45-11:05	*Title:* Responsive Self-assembly Nanosystem for Tumor Theranostics *Dr. Daxiang Cui,* Professor, Shanghai Jiao Tong University, China
11:05-11:30	*Title:* New Tridentate Ligands for Practical Asymmetric Hydrogenation *Dr. Xumu Zhang,* Chair Professor, Southern University of Science and Technology, China
11:30-11:55	*Title:* Intelligent Manufacturing of Microbial Drugs *Dr. Lixin Zhang,* Professor and Director, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, China
11:55-12:30	High-end Dialogue (Part I) Topic: What Are the Three Pain Points of Innovative Drug Development? Chair: Dr. Yinsheng Zhang, Vice President of Pharmaceutical R&D, Jiangsu Key Laboratory of Targeted Antiviral Research, Chia Tai Tianqing Pharmaceutical Group Co., Ltd, China Guests: *Dr. Lianshang Zhang,* SVP and President of Global R&D of Hengrui Pharmaceutical Co., China *Dr. Jonathan Liu,Chief Executive Officer, BeiGene Bioisland Innovation Center; Chairman of the Board, BeiGene Biologics, Co., Ltd.; Managing Director of BeiGene China BioVentures., China Dr. Aimin Hui,* Executive President, President of Global R&D Center, Chief Medical Officer, Co-President of Shanghai Fosun Pharmaceutical Development Co., Ltd., China *Dr. Satheeshkumar Sriharan,* Country Head, Dr.Reddy's Pharma, China *Dr. Lee Jia,* Distinguished Professor, Minjiang University, China (Fellow of AAPS and Academician of International Eurasian Academy of Sciences) *Dr. Xinpo Jiang,* Assistant Vice President, Reagent Product R& D Department, GenScript, China

Plenary Forum (Part II)
Time: 14:00-17:30, September 25, 2021 (Saturday); Place: Room 302, 3F, DICC

Chair	*Dr. Qun (Max) Dang,* President, Genuine Biotech, China

14:00-14:05	Moderator's Introduction
14:05-14:25	*Title:* The Rise and Challenges of New Drug R &D in China *Dr. Jing Li,* Chairman and Co-founder, Pharmacodia (Beijing) Co., Ltd., China
14:25-14:45	*Title:* Exploitation of the Emerging Chemical Elements in Drug Discovery *Dr. Yinsheng Zhang,* Vice President of Pharmaceutical R&D??Jiangsu Key Laboratory of Targeted Antiviral Research, Chia Tai Tianqing Pharmaceutical Group Co., Ltd, China
14:45-15:05	*Title:* The Application of Prodrug Technology in the Discovery of New Drugs with Enhancement *Dr. Qun (Max) Dang,* President, Genuine Biotech, China
15:05-15:25	*Title:* Targeting Ras Mutation with TCR Therapy *Dr. Yi Jin,* Chief Scientific Officer, Genbase Biotechnology, China
15:25-15:40	Coffee Break
15:40-16:00	*Title:* Structure-Based Drug Design, Common Issues and Recent Progress *Dr. Guosheng Wu,* Vice President, Computational Drug Discovery, Pharmaron, China
16:00-16:20	*Title:*Abnormal Lipid Metabolism and Mechanism of Omega-3 Unsaturated Fatty Acid Treatments in Depression: From Experimental Lab to Clinical Bed *Dr. Cai Song,* Director and Professor, Research Institute for Marine Drugs and Nutrition, and Shenzhen Institute, Guangdong Ocean University, China
16:20-16:40	*Title:* Remove IgG1 Fc Function for Better Efficacy and Safety *Dr. Maohua Li,* Vice President, AbMax Biotechnology Co., China
16:40-17:00	*Title:* High-throughout Innovative Therapeutic Antibody Discovery and Service Platform *Dr. Yongcong Tan,* Senior Project Director, Sanyou biopharmaceuticals Co., Ltd, China
17:00-17:30	High-end Dialogue (Part II) Topic: Under the New Government Rules of Generic Medicine Purchasing, Where the Future Lies for metoo Drugs in China? Chair: Dr. Qun (Max) Dang, President, Genuine Biotech, China Guests?? *Dr. Chun-Lin Chen,Chief Executive Officer, Shanghai Medicilon Inc., China Dr. Andrew C. Huang,* Chief Scientific Officer, MabPlex International Ltd., China *Dr. Yi Jin,* Chief Scientific Officer, Genbase Biotechnology, China *Dr. Yong Qian,Chairman, BioMedicure Group, China & USA Dr. Hongzhong (Thomas) Wu,*Vice President, Micot Technology Limited Company (Former Executive Director, Tasly Capital), China

Plenary Forum (Part III)
Time: 08:30-12:10, September 26, 2021 (Sunday); Place: Room 307A, 3F, DICC

Moderator	*Dr. Jonathan Liu,*Chief Executive Officer, BeiGene Bioisland Innovation Center; Chairman of the Board, BeiGene Biologics, Co., Ltd.; Managing Director of BeiGene China BioVentures., China

08:30-08:35	Moderator's Introduction
08:35-09:00	*Title:* S-nitrosocaptopril: A New Drug for Both Pulmonary Artery Hypertension and COVID-19-induced Acute Respiratory Distress Syndrome (ARDS) *Dr. Lee Jia,* Distinguished Professor, Minjiang University, China (Fellow of AAPS and Academician of International Eurasian Academy of Sciences)
09:00-09:25	*Title:* Manufacturing of Therapeutic Antibodies at Commercial Stage: Cost Analysis, Choices, and Beyond *Dr. Yansheng Xie,*Senior Vice President, Zhejiang Teruisi Pharmaceuticals, China
09:25-09:50	*Title:* Global Drug Development Strategy in there Era of ICH *Dr. Dan Zhang,* Co-Founder and Chief Strategy Officer, ClinChoice Inc., China; Foreign Member of Russian Academy of Engineering
09:50-10:15	*Title:* CAR Structure, Process and Analytical Method Developments *Dr. Zodiac Zhang,* Head of Antibody and Protein Products, GenScript Biotech Corp. LTD, China
10:15-10:30	Coffee Break
10:30-10:55	*Title:* Embrace Healthcare Reform though Innovations *Dr. Jonathan Liu,*Chief Executive Officer, BeiGene Bioisland Innovation Center; Chairman of the Board, BeiGene Biologics, Co., Ltd.; Managing Director of BeiGene China BioVentures., China
10:55-11:20	*Title:* Expanding Chemical Space for Drug Discovery by DEL Technology *Dr. Jin Li,*Chairman & CEO, HitGen Ltd., China
11:20-11:45	*Title:*Stem Cell Clinical Research Project Registration Process *Dr. Jing Liu,*Secretary, the Party committee of The First Affiliated Hospital of Dalian Medical University; President, Dalian Stem Cell and Precision Medicine Innovation Institute, China
11:45-12:10	*Title:*Conditional Reprogrammed Cells for Living Biobank, Regenerative Medicine and Individualized Cancer Therapy *Dr. Quanshun Zhang,* Senior Scientist, IIVS, USA

BIT's 11^th World Gene Convention (WGC)

WGC 01: Advances in Molecular & Cell Biology
Time: 08:30-10:15, September 26, 2021 (Sunday); Place: Room 621, 6F, DICC

Chair	*Dr. Shangli Shi,* Professor, Gansu Agricultural University, China

08:30-08:35	Chair's Introduction
08:35-08:55	*Title:* Oocyte IVM or Vitrification Significantly Impairs DNA Methylation Patterns in Blastocysts as Analysed by Single-Cell Whole-Genome Methylation Sequencing *Dr. Xueming Zhao,*Professor, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, China
08:55-09:15	*Title:*MicroRNA-574-5p in Gastric Cancer Cells Promotes Angiogenesis by Targeting Protein Tyrosine Phosphatase Non-receptor Type 3 (PTPN3) *Dr. Qing Yang,* Professor, Jilin University, China
09:15-09:35	*Title:* Plant Peptides (NCRs) and Plant Immunity Play Vital Roles in Determining Specificity between Alfalfa Cultivars and Sinorhizobium Meliloti Strain *Dr. Wenjuan Kang,* Lecturer, Gansu Agricultural University, China
09:35-09:55	*Title:* Complementary Analyses of the Transcriptome and iTRAQ Proteome Revealed Mechanism of Ethylene Dependent Salt Response in Bread Wheat (Triticum aestivum L.) *Dr. Qian Ma,* Associate Professor, Qingdao Agricultural University, China
09:55-10:15	*Title:* Proteomes Reimagined, and Precision Medicine with Long Non-coding RNA *Dr. Leonard Lipovich,* Professor, Mohammed Bin Rashid University of Medicine and Health Sciences, UAE (Video)

WGC 02: Updates on Genetics & Genomics
Time: 10:30-12:25, September 26, 2021 (Sunday); Place: Room 621, 6F, DICC

Chair	*Dr. Hua Wang,* Professor, Anhui Medical University, China

10:30-10:35	Chair's Introduction
10:35-10:55	*Title:*Bovine Stearoyl-CoA Desaturase 1 Promotes Adipogenesis by Activating the PPARγ Receptor *Dr. Anning Li,* Associate Professor, Northwest A&F University, China
10:55-11:15	*Title:* Environmental Exposure to Cadmium Impairs Fetal Growth and Placental Angiogenesis via GCN-2-Mediated Mitochondrial Stress *Dr. Hua Wang,* Professor, Anhui Medical University, China
11:15-11:35	*Title:* Gestational Exposure to Environmental Cadmium Induces Placental Apoptosis and Fetal Growth Restriction via Parkin-Modulated MCL-1 Degradation *Dr. Longhua Zhu,* Anhui Medical University, China
11:35-11:55	*Title:* Population Genetics and Genome-Wide Association Mapping of Chinese Populations of Foxtail Millet and Green Foxtail *Dr. Guanqing Jia,* Professor, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, China (Video)
11:55-12:15	*Title:* Epigenetic-Modification Mediated Phenotype Variations in Psychiatric Disorders *Dr. Cunyou Zhao,* Professor, Southern Medical University, China (Video)
12:15-12:25	*Title:* Remote Bioholography via the RNA Wave Modulation of Refraction Code in the Wave Optics of the DNA Scalar Wave Diffraction Grating *Dr. Irene Caesar,* President, Wave Genome LLC, USA (Video)

WGC 03: Molecular Mechanism of Disease, Drug Targeting and BioDrugs
Time: 08:30-10:15, September 27, 2021 (Monday); Place: Room 622, 6F, DICC

Chair	*Dr. Yandong Wang,* Professor, Beijing University of Chemical Technology, China

08:30-08:35	Chair's Introduction
08:35-08:55	*Title:*Process Analytical Technology-Based Oligonucleotides Synthesizer to Assist Commercial Production of Therapeutic for mRNA and Genetic Diseases *Dr. Guorong Li,* Adjunct Professor, Suzhou University of Science and Technology, China
08:55-09:15	*Title:*miRNAs in Liver Diseases *Dr. Yandong Wang,* Professor, Beijing University of Chemical Technology, China
09:15-09:35	*Title:*Muscle-Specific Programmed Cell Death 5 Deletion Attenuates Cardiac Aging *Dr. Hongxin Zhu,* Associate Professor, Shanghai Jiao Tong University, China
09:35-09:55	*Title:*The Bile Acid Receptors FXR and TGR5 in Cancers *Dr. Weidong Chen,* Professor, Henan University, China
09:55-10:15	*Title:* TMEM16A Ion Channel, a Rising Anti-Cancer Drug Target *Dr. Yafei Chen,* Vice Professor, Hebei University of Technology, China
10:15-10:30	Coffee Break

WGC 04: Innovations inGene (Video)

1	*Title:* Meta Analysis of Brain Transcriptome Data in Autism Spectrum Disorder *Dr. Payal Trivedi,* Research Scholar, Amity Institute of Biotechnology, Amity University,India
2	*Title:* Meta Analysis as a Promising Functional Genomic Assay for Neurodevelopmental Disorders *Dr. Prachi Srivastava,* Assistant Professor, Amity Institute of Biotechnology, Amity University, India
3	*Title:* As-Tolerant P-A Strain of Pantoea Ananatis: A Potential PGPR, Isolated from the Hezhou Mining Area in China *Dr. Fiza Liaquat,* Shanghai Jiao tong University Minhang, China
4	*Title:* Combined Clinical and Laboratory Diagnostics of Neurodegenerative Disorders *Dr. Alena Sidenkova,* Professor, Ural State Medical University, Russia
5	*Title:* Targeting PPIs with Stabilized Peptides for Biomedical Applications *Dr. Feng Yin,* Associate Professor, Pekinsg University Shenzhen Graduate School, China
6	*Title:*A Novel Peptide-Nucleic Acid Nano Co-Delivery System for Tumor Immunotherapy *Dr. Yaping Zhang,* Doctor, Peking University Shenzhen Graduate School, China
7	*Title:* Generation and Characterization of Affibody Affinity Probes to Ephrin B3 in Non-Small Cell Lung Cancer *Dr. Johan Nilvebrant,* Researcher, KTH - Royal Institute of Technology, Sweden