BIT's 9th Annual World Protein & Peptide Conference
★ Scientific Program
BIT’s 9th
Annnual World Protein & Peptide Conference -2016

Theme: Translation, Health and Happiness
Time: April 25-28, 2016
Venue: Dalian International Conference Center (DICC), Dalian, China

Registration
Time: 08:30-18:00, April 24-25, 2016; Place: Dalian International Conference Center (DICC)
Time: 18:30 -22:00, April 24, 2016 (Sunday); Lobby, 1st Floor, Hilton Dalian
Time: 08:30 -22:00, April 24, 2016 (Sunday); Lobby, 8th Floor, Swish-hotel Dalian

 

Group Photo
Time: 08:20-08:30, April 25, 2016 (Monday); Place: South Outside of the Square, DICC

 

Opening Ceremony and Plenary Forum

Opening Ceremony
Time: 09:00-09:30, April 25, 2016 (Monday); Place: Room 303, 3rd Floor, DICC

 

Plenary Forum
Time: 09:30-11:40, April 25, 2016 (Monday); Place: Room: 303, 3rd Floor, DICC
Moderator Dr. Mingde Xia, Senior Director, Johnson & Johnson Innovation, USA
09:30-09:35 Moderator's Introduction
09:35-10:00 Title: How to Model the Action of Complex Biological Systems on a Molecular Level
Dr. Arieh Warshel,Distinguished Professor, University of Southern California, USA
Nobel Prize Laureate in Chemistry, 2013
10:00-10:25 Title: Understanding Human Health and Disease with LC/MS Based Metabolic Phenotyping
Prof. Robert Plumb, Professor, Imperial College London, UK
Fellow of the Royal Society of Chemistry
10:25-10:50 Title: A Novel Genetic System for Medical/Biotech Development of Longevity, Juvenescence, And Tumor Resistance
Dr. Che-Kun James Shen, Distinguished Research Fellow, Institute of Molecular Biology, Academia Sinica, Taiwan
Elected Fellow of the American Association for the Advancement of Science (AAAS) and the Third World Academy of Sciences, Academician of the Academia Sinica
10:50-11:15 Title: TBD
Dr. Patrick Liu, Vice President, Teva Pharmaceuticals Ltd., USA
11:15-11:40 Title: Bispecific Antibodies Finally Come of Age
Dr. William Strohl, Vice President, Janssen Research & Development, LLC, USA

 

Keynote Forum of PepCon & ICA & WCV
Time: 14:30-17:05, April 25, 2016 (Monday); Place: Room: 307, 3rd Floor, DICC
 
Moderator Dr. Matthew He, Professor, Nova Southeastern University, USA
 
14:30-14:35 Moderator's Introduction
14:35-15:05 Title: Immunogenicity of Antibody Therapeutics: Laboratory Testing and Clinical Impact
Dr. Patrick Liu, Vice President, Teva Pharmaceuticals Ltd., USA
15:05-15:35 Title:The Promise of Peptide Drugs to Alleviate Medical Needs
Dr. Jose de Chastonay,Chief Marketing Officer, Bachem Holding AG, Switzerland
15:35-16:05 Title: Present State and Challenges of Peptidomics
Dr. Vadim Ivanov, Professor, Director, Russian Academy of Sciences, Russia
16:05-16:35 Title: Recent Developments and Challenges of Peptidomic Research
Dr. Priyabrata Pattnaik, Director of Worldwide Vaccine Initiative, Merck , Singapore
16:35-17:05

Title: Introduction of Industrial Parks

Aisi Fu, Director of Public Technical Services Department, Wuhan Institute of Biotechnology, China

 

Session 1: Protein Folding, Structure, Dynamics and Functions
Time: 08:30-10:55, April 26, 2016 (Tuesday); Place: Room: 621, 6th Floor, DICC
 
Chair Dr. Delia Picone, Professor, The University of Naples Federico II, Italy
Co-Chair Dr. Li-Ming Chen, Associate Professor, Huazhong University of Science and Technology, China
 
08:30-08:35 Chair's Introduction
08:35-08:55 Title: Full Prediction for Protein Structure Conformations
Dr. Jiaan Yang, CSO, Micro Pharmtech Ltd., China
08:55-09:15 Title: Design of Protein Based Sweeteners: Hints from Structure Function Relationships
Dr. Delia Picone, Professor & Group Leader, University of Naples Federico II, Italy
09:15-09:35 Title: Protein-Protein Interaction Dynamics Is Critical to the Function and Robustness of the Cyanobacterial Circadian Clock
Dr. Sen Liu, Deputy Director, Hubei Key Lab of Tumor Microenvironment and Immunotherapy, China Three Gorges University, China
09:35-09:55 Title: Functional Role of Reactive Astrocytes in Injured Mouse Brain
Dr. Hiroko Ikeshima-Kataoka, Assistant Professor, Waseda University; Part-time Assistant Professor, Part-time Assistant Professor, Keio University School of Medicine, Japan
09:55-10:15 Title: Bicarbonate Transporters of SLC4 Family: Structure, Function, and Physiological Roles
Dr. Li-Ming Chen, Associate Professor, Huazhong University of Science and Technology, China
10:15-10:35 Title: Backbone Conformations of Unfolded Peptides: A Polyproline II Propensity Scale Derived from AcPXPNH2
Dr. Zhengshuang Shi, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, China
10:35-10:55 Title: Chimeric Ubiquitin Ligases Inhibit Non-small Cell Lung Cancer via Negative Modulation of EGFR Signaling
Dr. Daixing Zhong, Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, China

 

Session 2: Protein Analytical Technologies
Time: 10:15-12:20, April 26, 2016 (Tuesday); Place: Room: 622, 6th Floor, DICC
 
Chair Dr. Ashraf Elamin, Manager Proteomics, Philip Morris International, Neuchatel, Switzerland
 
10:15-10:20 Chair's Introduction
10:20-10:40 Title: Langmuir Monolayer Techniques to Deposit Protein Layers onto Solid Supports
Dr. Taiji Furuno, Professor, Keio University School of Medicine, Japan
10:40-11:00 Title: Comparative Quantitative Proteomics Studies on Mice Lung Proteome for the Assessment of Candidate Modified Risk Tobacco Products
Dr. Ashraf Elamin, Manager Proteomics, Philip Morris International, Neuchatel, Switzerland
11:00-11:20 Title: Some Like It Hot: Immobilization-free Biomolecule Analytics by Microscale Thermophoresis (MST) and Exploring Protein Stability by NanoDSF
Dr. Zhuo Li, Senior Application Specialist, NanoTemper Technologies GmbH, Germany
11:20-11:40 Title: RF Antenna-based Biosensor Design, Modelling and Simulation for Continuous Microbial Pathogen Detection
Dr. Sunday Ekpo, Principal Investigator & Lecturer, RF/Microwave Communication & Space Systems Engineering, Manchester Metropolitan University, UK
11:40-12:00 Title: Development of Fluorescent Magnetic Particles for “On-Off” Switching based Detection of Various Lectin-saccharide Interactions
Dr. Yoshio Suzuki, Principal Researcher, National Institute of Advanced Industrial Science and Technology, Japan
12:00-12:20 Title: Screening E3 Substrates Using a Live Phage Display Library
Dr. Youhe Gao, Professor, Beijing Normal University, China

 

Session 3: Protein Engineering
Time: 13:30-16:15, April 26, 2016 (Tuesday); Place: Room: 621, 6th Floor, DICC
 
Chair Dr. Zoran Sosic, Senior Scientist, Biogen Idec, USA
Co-Chair Dr. Guangli Wang, Vice President, OriGene Technologies, Inc., USA
 
13:30-13:35 Chair's Introduction
13:35-13:55 Title: Analytical Characterization of Antibody Drug Conjugate
Dr. Xueying Huang, Founder and President, Sepax Technologies, Inc., USA; Founder and President, Suzhou Sepax Technologies, Inc., China
13:55-14:15 Title: Glycan Analysis in Biopharmaceutical Development: From Bioreactor to Purified Drug Substance
Dr. Zoran Sosic, Senior Scientist, Analytical Development, Biogen, USA
14:15-14:35 Title: Development of Expression Systems for Production of Useful Proteins
Dr. Michihiko Kobayashi, Professor,  University of Tsukuba, Japan
14:35-14:55 Title: Secretory Production of Recombinant Proteins Using ABC Transporter in Gram Negative Bacteria
Dr. Jung Hoon Ahn, Professor, Korea Science Academy of KAIST, South Korea
14:55-15:15 Title: Flexible and High throughput Transient Expression of Full-Length Human Proteins in Human Cells
Dr. Guangli Wang, Vice President, OriGene Technologies Inc., USA
15:15-15:35 Title: Expression and Purification of Recombinant Proteins in Escherichia coli Tagged with the Metal-Binding Proteins CusF and SmbP
Dr. Xristo Zarate, Associate Professor, Autonomous University of Nuevo Leon, Mexico
15:35-15:55 Title:Diagnostic and Therapeutic Applications of Fusion Antigens from Mycobacterium Tuberculosis
Dr. M. Waheed Akhtar, Professor, University of the Punjab, Pakistan
15:55-16:15 Title: Scientific Questions of Peptide-mapping Analysis of Protein/Antibody
Dr. Suxia Li, Professor, East China University of Science and Technology, China

 

Session 4: Plasma Proteins with Health/Diseases
Time: 15:15-17:20, April 26, 2016 (Tuesday); Place: Room: 625, 6th Floor, DICC
 
Chair Dr. Karin Magnussen, Medical Director, Copenhagen University Hospital, Denmark
Co-Chair Dr. Claudia Nardini, Senior Internal Specialist, Kedrion Biopharma, Italy
 
15:15-15:20 Chair's Introduction
15:20-15:40 Title: Molecular and Functional Characterization of Gly-317 Variants Of Factor IX in Hemophilia B Patients with Different Degree of Bleeding
Dr. Likui Yang, Assistant Professor, St. Louis University, USA
15:40-16:00 Title: Characterization of Blood Donors with High Haemoglobin Concentration
Dr. Karin Magnussen, Medical Director, Copenhagen University Hospital, Denmark
16:00-16:20 Title: Modulation of the Unfolded Protein Response by Photobiomodulation: Implications for the Prevention of Chronic Pain and Post-operative Cognitive Dysfunction (POCD)
Dr. Ann Liebert, Clinician & Researcher, University of Sydney, Australia
 

 

16:20-16:40

Title: Proteomic Differential Displays of Human Plasma Protein
Dr.Tai-Yuan Chen,  National Taiwan Ocean University, Taiwan
16:40-17:00 Title: Anti-A/B Hemagglutinin Depletion during Cohn Purification Process of 5% Immunoglobulin
Dr. Claudia Nardini, Senior Internal Specialist, Kedrion Biopharma, Italy
17:00-17:20 Title: Fatty acid-bearing Albumin Enhances the Expression and Function of BCRP Transporter via HIF-1 Activation in Renal Proximal Tubular Epithelial Cells
Dr. Junya Nagai, Professor, Osaka Univeristy of Pharmaceutical Sciences, Japan

 

Session 5: Protein and Drug Discovery, Therapeutic Antibodies
Time: 14:35-17:00, April 26, 2016 (Tuesday); Place: Room: 622, 6th Floor, DICC
 
Chair Dr. Miroslaw K. Gorny, Professor, Department of Pathology, New York University School of Medicine, USA
Co-Chair Dr. Rodney Prell, Principal Scientist/Toxicologist, Safety Assessment Department, Genentech, USA
 
14:35-14:40 Chair's Introduction
14:40-15:00 Title: Novel CD7-Specific Nanobody-Based Immunotoxins Potently Mediate Apoptosis of CD7-Positive Malignant Cells
Dr. Lin Yang, Professor, Soochow University; Chairman and CSO, PersonGen Biomedicine (Suzhou) Co., Ltd., China
15:00-15:20 Title: Characterization of HIV-1 Proteins by Human Monoclonal Antibodies
Dr. Miroslaw K. Gorny,Professor, New York University School of Medicine, USA
15:20-15:40 Title: Ertapenem, Seizures and the Elderly
Dr. Samuel TH Chew, Fellow, The Royal College of Physicians, UK; Adjunct Assistant Professor of Medicine, National University of Singapore, Singapore
15:40-16:00 Title: Antibodies Against Helicobacter Pylori Heat Shock Protein 60 Aggravate HSP60-Mediated Proinflammatory Responses
Dr. Nu-man Tsai, Associate Professor, Chung Shan Medical University, Taiwan
16:00-16:20 Title: Navigating Nonclinical Safety Challenges for Cancer Immunotherapy Drug Development
Dr. Rodney Prell, Principal Scientist & Toxicologist, Safety Assessment Department, Genentech, USA
16:20-16:40 Title: Eyes Can't See What Mind Doesn't Know
Dr. Alawi Aqel Alattas, Neurologist & Epileptologist, King Faisal Specialist Hospital, Kingdom of Saudi Arabia
16:40-17:00 Title: The New Requirements for Protein Purification Technology in Biological Pharmaceutical Industry
Dr. Li'an Guo, Xi'an Health Bio-tech Co., Ltd., China

 

Session 6: Novel Peptide Structure, Functions and Synthesis
Time: 16:15-17:40, April 26, 2016 (Tuesday); Place: Room: 621, 6th Floor, DICC
 
Chair Dr. Wolfgang Rapp, CEO, Rapp Polymere GmbH, Germany
 
16:15-16:20 Chair's Introduction
16:20-16:40 Title: Ultra High Speed Peptide Synthesis on Monosized Microparticles
Dr. Wolfgang Rapp, CEO, Rapp Polymere GmbH, Germany
16:40-17:00 Title:A Chirality Change in XPC- and Sfi1-Derived Peptides Affects their Affinity for Centrin
Dr. Liliane Assairi, Biochemist & Molecular Biologist, Institut Curie-Recherche, France
17:00-17:20 Title: Mechanism of Antifungal Activity of Antimicrobial Peptide APP against Candida Albicans: Intracellular DNA Binding and Cell Cycle Arrest
Dr. Lirong Li, Professor, Kunming University of Science and Technology, China
17:20-17:40 Title: Aldehyde Capture Peptide Ligation without Involving a Sidechain Functional Group
Dr. Junfeng Zhao, Jiangxi Normal University, China

 

Session 7: Protein-Protein Interactions, DNA/RNA-Protein Interactions
Time: 10:35-12:20, April 27, 2016 (Wednesday); Place: Room: 620, 6th Floor, DICC
 
Chair Dr. Matthew He, Director & Professor & EAI Academician, Nova Southeastern University, USA
 
10:35-10:40 Chair's Introduction
10:40-11:00

Title: DNA Sturctures and Knot Theory

Dr. Matthew He, Director & Professor & EAI Academician, Nova Southeastern University, USA

11:00-11:20

Title: From Determinants of Protein Binding Straight to Inhibitors of Protein-Protein Interactions

Dr. Holger Gohlke, Professor, Heinrich-Heine-University Dusseldorf, Germany

11:20-11:40

Title: Functional Mode of Small Heat Shock Proteins: On the Plant Side

Dr. Choo B. Hong, Professor, Seoul National University, South Korea

11:40-12:00

Title: 4F-acts, A Strategy to Discovery Protein Interactions In-Situ Sensitivity and Specifically
Dr. Youhe Gao, Professor, Beijing Normal University, China

12:00-12:20

Title: Nitroproteomics in Human Astrocytomas
Dr. Xianquan Zhan,
Professor, Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, Xiangya Hospital, Central South University, China

 

Session 8: Protein NMR Spectroscopy, Microscopy and Crystallography
Time: 08:30-11:15, April 27, 2016 (Wednesday); Place: Room: 622, 6th Floor, DICC
 
Chair Dr. Alex I. Smirnov, Professor, NC State University, USA
 
08:30-08:35 Chair's Introduction
08:35-08:55 Title: Analysis of Local Dynamics in Proteins Using CP-VC Solid-State NMR Experiment under Ultrafast MAS
Dr. Jean Paul Amoureux, Professor, East China Normal University, Physics Department & Shanghai Key NMRLaboratory, China; Unit of Catalysis and Chemistry of Solids, University Lille North of France, France
08:55-09:15 Title: Line Narrowing in NMR of Membrane Proteins Aligned by Nanopores
Dr. Alex I. Smirnov, Professor, North Carolina State University, USA
09:15-09:35 Title: Small Chemicals Triggered 53BP1 Dimerization
Dr. Gaofeng Cui, Assistant Professor, Mayo Clinic, USA
09:35-09:55 Title: Protein Propensity to Crystallize
Dr. Bo Y Baker, Case Western Reserve University, USA
09:55-10:15 Title: Copper Homeostasis in Bacteria Cells-Exploring Cellular Metal Transfer Pathways and Mechanisms
Dr. Sharon Ruthstein, Bar Ilan University, Israel
10:15-10:35 Title: Dough by Fluorescence Microscopy and Image Analysis
Dr.Tatsuro Maeda, Assistant Manager, Nisshin Foods Inc., Japan
10:35-10:55 Title: Rational Design and Synthesis of Fluorescence Biosensors for Quantitative Detection of Reactive Biomarkers
Dr. Run Zhang, Associate Professor, School of Chemical Engineering, University of Science and Technology, China; Research Fellow, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Australia
10:55-11:15 Title: Absolute Polarity of Teeth Cementum and Fish Bone by Phase Sensitive Second Harmonic Generation Microscopy
Dr. Hanane Oulevey-Aboulfadl, Postdoctor, University of Berne, Switzerland

 

Session 9: Late-Breaking Topics in Proteomics
Time: 13:30-15:35, April 27, 2016 (Wednesday); Place: Room: 621, 6th Floor, DICC
 
Chair Dr. Shao Chin Lee, Professor,Shanxi University, China
 
13:30-13:35 Chair's Introduction
13:35-13:55 Title: Global Phophoproteomics to Study EGFR TKI-Sensitive and Resistant Lung Adenocarcinoma
Dr. Udayan Guha,
Chief, NCI, NIH, USA
13:55-14:15 Title: Genome-wide Immune Profiling Using High Throughput Proteomics Tools
Dr. Xiaowu Liang,
President & CEO, ImmPORT Therapeutics Inc.; dba Antigen Discovery Inc., USA
14:15-14:35 Title: Comparative Quantitative Proteomics Studies on Mice Lung Proteome for the Assessment of Candidate Modified Risk Tobacco Products
Dr. Ashraf Elamin,
Manager Proteomics, Philip Morris International, Switzerland
14:35-14:55

 Title: Isolation of the TLP Encoding Cdna, Gene Sequence and Analysis of Its Expression Control

Dr. Giulio Tarro, President, Foundation T. & L. de Beaumont Bonelli for Cancer Research, Italy

14:55-15:15

Title: Proteomic Exploration of Venom in Cephalopod Sepia Officinalis
Dr. Céline Zatylny-Gaudin,
Normandy University, France

15:15-15:35 Title: Functional Proteomic Analysis Reveals that Graviola Extract Triggers Liver Cancer Cell Apoptosis through ER Stress Pathway
Ms. Hua Li Yang,
Shanxi University, China

 

 

Session 10: Bioactive Peptides and Novel Peptide Therapy
Time: 15:40-17:45, April 27, 2016 (Wednesday); Place: Room 621, 6th Floor, DICC
 
Chair Dr. Keith R. Davis, Director, Indiana University, USA
Co-Chair Dr. Min Wan, Assistant Professor, Karolinska Institutet, Sweden
 
15:40-15:45 Chair's Introduction
15:45-16:05 Title: Lunasin: A Multifunctional Anticancer Peptide from Soybean
Dr. Keith R. Davis, Director, Indiana University, USA
16:05-16:25 Title: Neuropeptidome of the Cuttlefish Sepia Officinalis: Identification of Neuropeptides that Regulate Egg-laying
Dr. Joël Henry, Professor, Normandy University, France
16:25-16:45 Title: Therapy with Radiolabeled Peptides: How Far Are We?
Dr. Kathleen Weyts, Nuclear Medicine Physician, CHU Brugmann, Belgium
16:45-17:05 Title: Cancer Vaccination with Peptide and Dendritic Cell Targeting Wilms' Tumor 1
Dr. Shigetaka Shimodaira, Professor, Shinshu University Hospital, Japan
17:05-17:25 Title: Human Antimicrobial Peptide LL-37 Modulates Bacterial Clearance and the Production of the Inflammatory Lipidsby Macrophages
Dr. Min Wan, Assistant Professor, Karolinska Institutet, Sweden
17:25-17:45 Title: Therapeutic Strategy with Japanese Kampo Medicine for Gastrointestinal Diseases based on the Gut-Regulated Peptide levels in Human Body Fluid
Dr. Yuhki Sato, Deputy Director, Oita University Hospital, Japan

 

Session 11: Clinical Application of Protein
Time: 10:30-12:15, April 28, 2016 (Thursday); Place: Room: 621, 6th Floor, DICC
 
Chair Dr. Sang Hee Lee, Director, Professor, Myongji University, South Korea
 
10:30-10:35 Chair's Introduction
10:35-11:00 Title: Clinical Evaluation of A Natural Polypeptide, Γ-PGA against Cervical Intraepithelial Neoplasia
Dr. Kyung-soo Hahm, Senior Advisor, BioLeaders Corporation, Korea
11:00-11:25 Title: Novel Carbapenem-Hydrolyzing Class C Extended-Spectrum B-Lactamase Isolated from Acinetobacter Baumannii Clinical Isolates
Dr. Sang Hee Lee, Director & Professor, Myongji University, Korea
11:25-11:50 Title: Clinical Application of Myeloperoxidase and Angiopoietin-like 4 in Pneumonia
Dr. Vincent TK Chow, Associate Professor, National University of Singapore, Singapore
11:50-12:15 Title: Use of C-Reactive Protein in the Diagnosis of Acute Cholecystitis
Dr. Andrei M. Belyaev, Cardiothoracic Registrar, Auckland City Hospital, New Zealand
 

 

 

 

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The "Nobel Across China Program" aims to encourage young scientists to learn the frontier knowledge and strengthen the scientific information exchange, to generate impact on basic research in life science between China and the rest of the world.

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